F06.7
Conditions
Interventions
Group 1: Patients with mild cognitive disorder: 1.) Repetitive training of naming
word learning. Naming, fluency and word learning will be tested using standard tests (e.g. animal names within 1 min). These repetitive training sessions will each only take a few minutes and will be
Sponsors
Abteilung Psychiatrie
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients: Diagnosis of MCI defined by a Z-score below -1.5 in one of the CERAD domains Controls: Normal kognitive functioning. Operationalised by Z-scores above -1.
Exclusion criteria
Exclusion criteria: Contraindikations against TMS or MRI. Psychoactive medication. Drug abusus. Severe neurological or psychiatric diseases. Age 80 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What? We plan to correlate the strength of potentiation measured using transcranial magnetic stimulation (TMS) with a paired associative stimulation protocol (PAS-TMS) with a potentiation induced by visually envoked potentials (VEP) measured usign functional magnetic stimulation. When? At the end of the second study day. How? A single variable results from PAS-TMS and VEP, both reflecting potentiation and plasticity. Those will be correlated. | — |
Secondary
| Measure | Time frame |
|---|---|
| What? Correlation between learning and genetics as well as with kognitive markers (e.g. slope of learning curve in naming, fluency, etc.) When? At the end of second study day and again after 2 months. How? The slop of the learning curve of each modality will be correlated against each other and against the variables from endpoint 1. | — |
Countries
Germany
Contacts
Public ContactJessica Peter
Uniklinik Freiburg
Outcome results
None listed