Effects of Renal Denervation on Ambulantory Blood Pressure and Hypertensive Target Organ Damages in Patients With Resistant Hypertension.

Effects of Renal Denervation on Ambulantory Blood Pressure and Hypertensive Target Organ Damages in Patients With Resistant Hypertension. - RDN-Halle

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00004173

Enrollment

200

Registered

2012-06-15

Start date

2011-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I10.0 I11.0 I10.1 I11.9 I12.0 I12.9

Interventions

Group 1: patients suffering of resistent hypertension with and without target organ damage following renal denervation diagnostic tests: echocardiography, cardiac MRI, ECG, 24-hour urine collection, b

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: -resistant hypertension (systolic office based BP >160mmHg non diabetic, >150mmHg diabetic, =3 antihypertensive medications) -written consent

Exclusion criteria

Exclusion criteria: missing consent, Age<18, secondary cause of hypertension, drug- or alcohol-addiction, psychiatric disease, encephalopathy, physical and mental challenges, that prevent registry attendance

Design outcomes

Primary

Measure	Time frame
24h-ABPM: 3 months and 1 day before, as well as 1 day, 3, 6, 12 months after renal sympathetic denervation	—

Secondary

Measure	Time frame
Proteinuria: urine 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Creatinine clearance: 24h urine and calculated 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renal function: Serum creatinine and urea in serum 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renin / Aldosteron-ratio: serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Renal function: serum cystatin C in 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renal resistance index: color-coded duplex sonography 3 months and 1 day before and 3, 6, 12 months after renal denervation HBA1C, HOMA-INDEX: serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Blood lipids: LDL, HDL, cholesterol, TG in serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Cutaneous Advanced Glycation End Products (AGEs): AGE-Reader 3 months and 1 day and 3, 6, 12 months after renal denervation LV mass index: echocardiography and MRI 3 months and 1 day before and 3, 6, 12 months after renal denervation Diastolic dysfunction: LA volume index, E / e ', LVEF in echocardiography 3 months and 1 day before and 3, 6, 12 months after renal denervation LV hypertrophy ECG indices: Cornell, Sokolow, ECG strain pattern 3 months and 1 day before and 3, 6, 12 months after renal denervation Autonomic Dysfunction / HRV: 24h Holter ECG 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Heart failure: BNP in the serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Atherosclerosis: intima-media complex ACC 3 months and 1 day before and 3, 6, 12 months after renal denervation Vascular stiffness: pulse wave velocity, augmentation index 3 months and 1 day before and 3, 6, 12 months after renal denervation Autonomic reflexes: chemoreflex- and baroreflextesting 1 day prior to and 6 months after renal denervation Quality of	—

Measure

Time frame

Proteinuria: urine 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Creatinine clearance: 24h urine and calculated 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renal function: Serum creatinine and urea in serum 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renin / Aldosteron-ratio: serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Renal function: serum cystatin C in 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Renal resistance index: color-coded duplex sonography 3 months and 1 day before and 3, 6, 12 months after renal denervation HBA1C, HOMA-INDEX: serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Blood lipids: LDL, HDL, cholesterol, TG in serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Cutaneous Advanced Glycation End Products (AGEs): AGE-Reader 3 months and 1 day and 3, 6, 12 months after renal denervation LV mass index: echocardiography and MRI 3 months and 1 day before and 3, 6, 12 months after renal denervation Diastolic dysfunction: LA volume index, E / e ', LVEF in echocardiography 3 months and 1 day before and 3, 6, 12 months after renal denervation LV hypertrophy ECG indices: Cornell, Sokolow, ECG strain pattern 3 months and 1 day before and 3, 6, 12 months after renal denervation Autonomic Dysfunction / HRV: 24h Holter ECG 3 months and 1 day before and 1 day, 3, 6, 12 months after renal denervation Heart failure: BNP in the serum 3 months and 1 day before and 3, 6, 12 months after renal denervation Atherosclerosis: intima-media complex ACC 3 months and 1 day before and 3, 6, 12 months after renal denervation Vascular stiffness: pulse wave velocity, augmentation index 3 months and 1 day before and 3, 6, 12 months after renal denervation Autonomic reflexes: chemoreflex- and baroreflextesting 1 day prior to and 6 months after renal denervation Quality of

—

Countries

Germany

Contacts

Public ContactAlexander Plehn

Universitätsklinikum Halle Martin Luther Universität Halle/Wittenberg

alexander.plehn@uk-halle.de03455570

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026