Monocentre evaluation of morphological and neurocognitive alterations after whole brain radiotherapy using IMRT technique with hippocampal sparing and boost to the metastases

Monocentre evaluation of morphological and neurocognitive alterations after whole brain radiotherapy using IMRT technique with hippocampal sparing and boost to the metastases - Hipporad-mono

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003862

Enrollment

Registered

2016-02-18

Start date

2012-08-22

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C79.3

Interventions

Group 1: Whole-brain radiotherapy with hippocampal sparing and dose escalation to metastases Group 2: Historic controls treated without hippocampal sparing

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with 4-8 brain metastases of solid tumors with indication for WBRT Metastases of 5 - 35mm width RPA classification I and II Written informed consent

Exclusion criteria

Exclusion criteria: Cerebral lymphoma, metastases from germ cell tumors or SLCL RPA classification III lack of MRI tolerance acute neurologic symptoms demanding immediate therapy accompanying diseases with possible cognitive symptoms or white matter change antiepileptic medication: benzodiazepine, barbiturate, topiramat, hydantoine, valproic acid, carbamazepin demetia, depression, diabetes mellitus hypertensive encephalopathy metastases within the hippocampus or with 10mm range

Design outcomes

Primary

Measure	Time frame
Hippocampal volume change (based on MRI) 3 months after therapy	—

Secondary

Measure	Time frame
Change of memory performance (verbal learning) and quality of life, survival, local tumor control	—

Countries

Germany

Contacts

Public ContactOliver Oehlke

Klinik für Strahlenheilkunde Universitätsklinikum Freiburg

oliver.oehlke@uniklinik-freiburg.de0761-27094101

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026