C22
Conditions
Interventions
Group 1: Liver function tests, blood draws, and a Doppler ultrasound to determine the perfusion is planned one day prior to liver resection, and 6 hours after surgery as well as 1, 2, 3, 5, 10, 14 and
Sponsors
Charité - Universitätsmedizin Berlin, CCV
Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. male or female patients who will underwent partial liver resection 2. age over 18 years 3. written consent to participate in the study
Exclusion criteria
Exclusion criteria: 1. previours liver operation (Cholezystectomy is no liver operation) 2. severe infections 3. incompliant patients (because of mental disorders or drug abuse for example)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver failure: The current liver function capacity is determined preoperatively and postoperatively at specific time points (6h, 1,2,3,5,10,14 and 90 POD) using LiMAx test (methacetin breath test), liver failure is defined as persistent postoperative values ??of the breath tests 100 µg / kg / h , standard value is > 315 µg/ kg / h. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels and patterns of hepatocyte growth factor HGF, transforming growth factor beta 1 TGF-beta-1 to interleukin-6 IL-6, tumor necrosis factor alpha TNF-alpha, insulin, insulin-like growth factor 1 and growth hormone will be examined using ELISA. Measuring times are one day before the planned liver resection, and 6 hours after surgery and 1, 2, 3, 5, 10, 14 and 90 days postoperatively. Standard laboratory parameters will be examined in the running. The clinical outcome will be documented The complications according to Dindo et al. will be documented. | — |
Countries
Germany
Contacts
Public ContactAntje Schulz
Charité - Universitätsmedizin Berlin, CCV Klinik für Allgemein-, Viszeral- und Transplantationschirurgie
Outcome results
None listed