Multi- versus Single Injection Technique for Peripheral Nerve Blockaded: A Volunteer Study

Multi- versus Single Injection Technique for Peripheral Nerve Blockaded: A Volunteer Study - 3D volunteers´study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

DRKS

Registry ID

DRKS00003826

Enrollment

Registered

2012-07-05

Start date

2012-06-26

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

Group 1: The nerve block will be performed with a multi-injection technique with the target of a circumferential distribution of LA (like a “doughnut”) and a maximum volume of LA of 5 mL Group 2: The

Eligibility

Sex/Gender

Male

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: - Healthy male volunteers aged between 18 and 45 years - BMI < 30 kg/m2 - Written informed consent given by volunteers after being provided with detailed information about the nature, risks, and scope of the clinical study as well as the expected desirable and adverse effects of the drug - No legal incapacity and/or other circumstances rendering the volunteer unable to understand the nature, scope and possible consequences of the study

Exclusion criteria

Exclusion criteria: - Anatomical abnormalities of the forearm identified by physical examination - Use of NSAID during the last 2 weeks - Known allergy or hypersensitivity against ropivacaine or other amino-amide LA - Participation in another clinical study within the last 4 weeks prior to study - Coagulopathy - Abnormalities in ECG that are considered clinically relevant like AV-block or bradycardia - Unreliability and/or lack of cooperation - Other objections to participate in the study in the opinion of the investigator

Design outcomes

Primary

Measure	Time frame
Primary endpoint is the sensory spread of the block. Evaluation takes place with pin brick tests and will be evaluated after 2, 4, 6, 8, 10, 15, 20, 30, 60, 90,120,150, 180minutes until sensibility is completely recovered. Complete blockade is achieved when VAS=3 within 20 minutes.	—

Secondary

Measure	Time frame
Onset time and duration of the block	—

Countries

Austria

Contacts

Public ContactDaniela Marhofer

Medizinische Universität Wien, Universitätsklinik für Anäesthesie, Allgemeine Intensivmedizin und Schmerztherapie

daniela.marhofer@meduniwien.ac.at+43 1 40400 4100

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026