healthy subjects
Conditions
Interventions
Group 1: High physical activity group (as defined in inclusion criteria) 1) Magent resonance imaging (MRI) assessment as defined in primary and secondary Outcomes
2) Blood sample with analysis of parameters of neurogenesis
3) Neuropsychological assessment as defined in secondary outcomes.
Group 2: Low physical activity group (as defined in inclusion criteria) 1) Magent resonance imaging (MRI) assessment as defined in p
3) Neuropsychological assessment as defined in secondary outcomes.
Sponsors
Klinik für Psychiatrie und Psychotherapie, Universität Duisburg-Essen
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age > 55 2) Either physically fit or not: High exercise (3 x 1 hour of physical demanding activities per week) or low exercise with a negative history of regular physical demanding activites 3) If diabetes mellitus type II present: HBA1C<8%
Exclusion criteria
Exclusion criteria: 1) Major psychiatric diseases including current episode of depressive or mood disorder, sleep disorder, psychosis, substance misuse or dependency 2) Major neurological or other somatic diseases 3) Diabetes mellitus type I and type II with HBA1C>8% 4) Regular medication other than diabetes type II related medication 5) Febrile illness within 3 days of study participartion 6) Contraindications against MRI assessments (e.g. metal implementation)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional MRI activation of the Hippocampus in an associative memory task | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Functional MRI related prefrontal and parietal activations in visual two-back working memory task 2) Hippocampus volume 3) Blood parameters of neurogenesis 4) Neuropsychological assessment: a) Cambridge Neuropsychological Test Automated Battery Subtest Reaction Time b) Cambridge Neuropsychological Test Automated Battery Subtest Paired Associates Learning c) Cambridge Neuropsychological Test Automated Battery Subtest Intra- Extra-Dimensional Set Shift d) Cambridge Neuropsychological Test Automated Battery Subtest Delayed Matching to Sample e) Verbaler Lern und Merkfähigkeitstest (VLMT) verbal learning (German version of the Auditory Verbal Learning Test). f) Brief Visuospatial Memory Test Revised - visual Memory g) Stroop Test h) Trail Making Test A/B i) Controlled Oral Word Association Test j) Mehrfachwahl Wortschatz Intelligenztest B (German basic IQ Test) k) Wechsler Memory Scale Revised Subtest Logical Memory | — |
Countries
Germany
Contacts
Public ContactChristian Kärgel
Klinik für Psychiatrie und Psychotherapie, Universität Duisburg-Essen
Outcome results
None listed