Cardiovascular disease N18.9 I51.6
Conditions
Interventions
Group 1: Patients with CKD will be followed up for at least five years. An interview, physical examination and blood and urine samples will be collected at baseline, and annually thereafter.
Sponsors
Department of Nephrology and Medical Intensive Care, Charité Campus Virchow-Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Willing patients with approximately 50% reduction in kidney function (estimated GFR 30-60 ml/min) and/or proteinuria >500 mg/g creatinine or albuminuria >300mg/g creatinine. All patients who fulfill these criteria during the recruitment phase will be informed about the study and requested to sign the consent form. Those patients who provide a written informed consent will be in recruited in the study and followed for a minimum of five years. Any medication therapy is possible and does not affect the inclusion in the ICKD study.
Exclusion criteria
Exclusion criteria: Patients with any organ or bone marrow transplantation; or patients who have received chemotherapy because of any active malignant disease within two years prior to recruitment, or patients with NYHA class III or IV heart failure at baseline, or patients with non-Indian origin will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary renal endpoints include: 1) Requirement of renal replacement therapy (dialysis or transplant) 2) Persistent decline of GFR of at least 50% compared to baseline The primary cardiovascular endpoints include: 1) Non-lethal myocardial infarction (symptomatic or silent) 2) Non-lethal stroke 3) Intervention for peripheral arterial occlusion disease 4) Cardiovascular conditioned death (including sudden cardiac death) 5) Hospitalization caused for cardiovascular reason These endpoints will be recorded at each annual follow-up visit and in-between telephonic interviews during the entire five-year study period. The endpoints will be captured by direct interviews with the patients, hospital discharge summaries, doctor's letters and blood tests. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) General mortality 2) Malignancy 3) Hospitalizations 4) Acute kidney injury | — |
Countries
India
Contacts
Public ContactSeema Baid-Agrawal
Department of Nephrology and Intensive Medical Care, Campus Virchow Klinik, Charite Medical University
Outcome results
None listed