G24.9 R25.2
Conditions
Interventions
Group 1: control group (healthy), structural and functional mri
Group 2: Dystonia, structural and functional MRI study before and during treatment with botulinum toxin A (0, 3, 12 months)
Group 3: sp
Sponsors
Klinik f. Neurologie
FSU Jena
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: Group 1 (dystonia): evidence of cervical dystonia by a specialist for Neurology, exclusion of other causes for dystonia-like symptomes, right-handed, no other neurological diseases, no pre-medication, MRI compatibility Group 2 (spasticity): evidence of clinically significant spasticity of the right side of the body following an ischemic infarction by a media, right-handed, no other neurological diseases, no relevant pre-medication, MRI compatibility
Exclusion criteria
Exclusion criteria: Psychiatric comorbidity, counter indication for MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment response in group 1 (dystonia) and group 2 (spasticity) after 12 months under treatment with botulinum toxin: - Dystonia: UDRS (Unified Dystonia Rating Scale), TWSTRS (Toronto Western Spasmodic Torticollis Rating Scale) - Spasticity: MAS (Mod Ashworth scale), SERS (Spasticity Examination Rating Scale) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain reduction (interview with "German Pain Questionnaire") at 0, 3 and 12 months | — |
Countries
Germany
Contacts
Public ContactStefan Brodoehl
Klinik f. Neurologie FSU Jena
Outcome results
None listed