C34 C78.0
Conditions
Interventions
Group 1: stereotactic fractionated radiotherapy of small lung tumors in 3 to 5 fractions
Sponsors
Universitätsklinikum Freiburg, Klinik für Strahlenheilkunde
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - presence of one or two FDG-PET positive pulmonary nodules /= 60% - Life expectancy > 6 months - Age > 18 years (no other age limits) - Informed consent signed in accordance with institutional protocol
Exclusion criteria
Exclusion criteria: - NSCLC: FDG-PET N+ if not ruled out by mediastinoscopy or other tissue sampling - in metastases: disseminated progressive disease without local control to be reasonably expected by current treatment - Histologically proven SCLC - More than two lesions to treat - Diameter of tumor > 5cm - Systemic therapy +/- one week of treatment - psychological/mental status does not allow informed consent and participation in QoL assessments - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| local tumor control after two years of follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| - actuarial local progression free surviva - overall survival over two years of follow-up - standardized QoL (EORTC QLQ C30 and LC13) - individual QoL (SEIQoL-DW Score) - Toxicity of SR in small lung tumors (CTC score) - Feasibility of integrated cone beam CT for patient positioning in SR - Impact of respiratory gated FDG-PET/CT in SR planning and follow up - Detection of tumor progression by CT vs. FDG-PET | — |
Countries
Germany
Contacts
Public ContactUrsula Nestle
Universitätsklinikum Freiburg, Klinik für Strahlenheilkunde
Outcome results
None listed