vulnerability for stress-related psychiatric disorders, such as depression, posttraumatic stress disorder, alcohol dependence F32.9 F43.1 F10
Conditions
Interventions
Group 1: The investigation will be conducted using members of the Mannheim Study of Children at Risk (MARS), an epidemiological cohort study following a sample of 384 children at risk of later psychop
Sponsors
Zentralinstitut für Seelische Gesundheit,
Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
Eligibility
Sex/Gender
All
Age
24 Years to 26 Years
Inclusion criteria
Inclusion criteria: Current participants of the Mannheim Study of Children at Risk
Exclusion criteria
Exclusion criteria: Participants in the main study: current psychiatric disorder, psychiatric treatment, drug or alcohol abuse, neurological disorder and other serious medical conditions, left-handedness, metallic implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effects of genes and environmental adversity on the structure, function and connectivity of neural circuits involved in emotion regulation and reward processing. In detail, the following assessments will be conducted: (i) structural neuroimaging (voxel-based morphometry), (ii) diffusion tensor imaging (DTI), and (iii) functional neuroimaging using three experimental paradigms to assess BOLD fMRI combined with EEG response during the execution of an emotional arousal (face matching) task, a response conflict and inhibition (flanker) task, and a reward task (differential conditioning paradigm). | — |
Countries
Germany
Contacts
Public ContactSibylle Heinzel
Zentralinstitut für Seelische Gesundheit, Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters
Outcome results
None listed