Epigenetic effects of exposure to pre-, peri- and postnatal stress assessed in early infancy (subproject 1 of "Prä-, peri- und pOstnatal Stress in human and non-human offspring: Epigenetic Impact on DepressiON (POSEIDON)") / DIAbetes Mellitus - Obstetric and Neonatal Distress: Epigenetic Effects (DiaMOND E2)

Epigenetic effects of exposure to pre-, peri- and postnatal stress assessed in early infancy (subproject 1 of "Prä-, peri- und pOstnatal Stress in human and non-human offspring: Epigenetic Impact on DepressiON (POSEIDON)") / DIAbetes Mellitus - Obstetric and Neonatal Distress: Epigenetic Effects (DiaMOND E2) - POSEIDON / DiaMOND E2

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003600

Enrollment

400

Registered

2012-03-19

Start date

2011-03-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 E11

Interventions

Group 1: Early life stress will be charakterized by history, questionnaires, saliva cortisol (mothers) and cortisol in diaper urine. We will use the following instruments: Perceived Stress Scale, Muni

Eligibility

Sex/Gender

Female

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: mother = main caregiver, German-speaking, no severe physical disease, no psychiatric disorder requiring inpatient treatment, birth weight > 1500 gr, gestational age > 32 weeks, AGPAR > 7

Exclusion criteria

Exclusion criteria: twin birth, major birth trauma of child or other major handicap

Design outcomes

Primary

Measure	Time frame
As outcome variables, we will investigate genome-wide methylation patterns (cord blood at birth) in extreme groups and their changes during early infancy (buccal mucosa swab at birth and 6 months).	—

Secondary

Measure	Time frame
Methylation of promoters of candidate genes for depression and diabetes and their change during course of observation (birth, 6 months postpartal).	—

Countries

Germany

Contacts

Public ContactMichael Deuschle

Zentralinstitut für Seelische Gesundheit

michael.deuschle@zi-mannheim.de0621 1703 2331

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026