Pediatric inflammatory bowel disease K50 K51
Conditions
Interventions
Group 1: Children and adolescent with suspicion of inflammatory bowel disease - and later histological confirmation. The investigations will be performed on tissue samples obtained during routine colo
control group). The investigations will be performed on tissue samples obtained during routine colonoscopies - no separate interventions for this study are necessary. mRNA expression levels of differe
Sponsors
Universitätsklinik für Kinder- und Jugendheilkunde, Medizinische Universität Graz
Eligibility
Sex/Gender
All
Age
6 Years to 19 Years
Inclusion criteria
Inclusion criteria: Children and adolescent with suspicion to inflammatory bowel disease Diagnosis of CU or UC on the basis of endoscopic and histological findings Children and adolescent without histological findings serve as control group Children and adolescent with "follow-up" colonoscopy (in case of known inflammatory bowel disease or other medical indication like familiary polyposis coli) Age 6-19 years, male, female Written inform consent (signature of parents / legal guardin) Medical ability to undergo colonoscopy
Exclusion criteria
Exclusion criteria: Missing signature on written consent Contraindication for colonoscopy with mucosal biopsies Existing other severe disease (anemia, pathologic coagulation tests or anticoagulant medication etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study investigate molecular expression level changes of different intestinal bile acid transporters, detoxifying systems and nuclear receptors in children and adolescent with inflammatory bowel disease. Therefore in intestinal biopsy specimens from children suffering from inflammatory bowel disease mRNA levels are investigated with the help of the real time PCR method (polymerase chain reaction). | — |
Countries
Austria, United States
Contacts
Public ContactJörg Jahnel
Medizinische Universität Graz
Outcome results
None listed