Impact of bariatric surgery on both central serotonin- and norepinephrine transporter (SERT/ NET) availability in obese subjects using positron emission tomography (PET) and selective radio-labelled marker before and 6 months after surgery

Impact of bariatric surgery on both central serotonin- and norepinephrine transporter (SERT/ NET) availability in obese subjects using positron emission tomography (PET) and selective radio-labelled marker before and 6 months after surgery - IFB-PET Bariatrie

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00003571

Enrollment

Registered

2012-08-30

Start date

2013-08-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66 F50

Interventions

Group 1: 30 obese patients (BMI >40kg/m2) selected for bariatric surgery undergoing DASB-PET before surgery and 6 month afterwards. In addition a MRI, blood withdrawals ( laboratory data, leptin/ghrel

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: • Age between 18 and 70 • BMI > 40 kg/m2 • no psychotropic-medication and/or drugs for at least 8 weeks prior PET • written informed consent

Exclusion criteria

Exclusion criteria: • History of neurological or psychiatric diseases • Structural lesions (stroke, traumatic brain injury etc.) • Cognitive deficits, major speech impairment, alcohol- or drug abuse (positive drug test) • Major mental disorders, major communicative deficiencies which inhibit an informed consent • neurosurgical interventions in the past • migraine • Epilepsy, cerebral seizures in previous medical history (or in history of the family) • Chronic diseases (e.g. asthma) indicating chronic medical treatment with central effect • Pregnancy • Contraindications for MR imaging (e.g., implanted ferro-magnetic devices), claustrophobia

Design outcomes

Primary

Measure	Time frame
quantified central SERT /NET availability (binding-potential BP and distribution volume [ratios] DV[R]) in obese patients (BMI = 40 kg/m2) undergoing bariatric surgery before and afterwards.	—

Secondary

Measure	Time frame
Correlation of BP and DVR values with the following parameters: genotype, stress reaction, age, gender. Comparison of the obese subjects before and 6 month after bariatric surgery.	—

Countries

Germany

Contacts

Public ContactFranziska Zientek

Univesitätsklinikum Leipzig Klinik und Poliklinik für Nuklearmedizin

franziska.zientek@medizin.uni-leipzig.de+49 341/ 97 18048

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026