K90.0
Conditions
Interventions
Group 1: Children with high suspicion of Celiac Disease due to elevated blood markers (CD specific autoantibodies) who will be reanalyzed for these blood markers and will undergo small bowel biopsy.
Sponsors
Klinikum der Ludwig-Maximilians-Universität
Dr. von Haunersches Kinderspital
Eligibility
Sex/Gender
All
Age
6 Months to 17 Years
Inclusion criteria
Inclusion criteria: Consecutive children (age > 6 months - 1:10).
Exclusion criteria
Exclusion criteria: • patient with symptoms that may indicate CD, but negative specific antibodies (TG2 or EMA), but normal IgA • patient without symptoms, and negative Anti-TG2 and negative EMA • malignancy • serious chronic infections such as HIV or tuberculosis or congenital immunodeficiency • contraindications for endoscopy/biopsies • Parents did not sign consent form • Parents can not read/are not able to understand to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In patients with highly increased Anti-TG2-levels (about 7-10fold upper normal limit) plus symptoms and/or high risk for CD: accordance of CD diagnosis based on the new guidelines of the ESPGHAN and results of histological examinations respectively discordance between CD diagnosis based on new guidelines and histology. | — |
Countries
Austria, Belgium, Croatia, Czechia, Denmark, Finland, France, Germany, Greece, Hungary, Iran, Israel, Italy, Netherlands, Poland, Portugal, Romania, Russia, Slovenia, Spain, United Kingdom
Contacts
Public ContactKatharina Werkstetter
Klinikum der Ludwig-Maximilians-Universität Dr. von Haunersches Kinderspital
Outcome results
None listed