ARDS (acute respiratory distress syndrome) pneumonia J18.0 J80 J45.9 J44
Conditions
Interventions
Group 1: pneumonia-patients (bronchoscopy with BAL, blood samples)
Group 2: ARDS-patients (bronchoscopy with BAL, blood samples)
Group 3: healthy subjects (bronchoscopy with BAL, blood samples)
Group
Sponsors
Abteilung Pneumologie
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a) diagnosis of pneumonia with diagnostic indication to perform bronchoscopy with BAL b) intubated patients with following clinical and radiological criteria of ARDS and indication to perform bronchoscopy with BAL: - acute onset of respiratory worsening within 38 to 72 hours - bilateral infiltrats in chest x-ray - PaO2/FiO2 <300mmHg - No suspected left arterial pressure c) Healthy subjects: Nomal values in laboratory and lung function testing
Exclusion criteria
Exclusion criteria: in a) and b) NO clinical indication to perform bronchoscopy a) in patients with pneumonia: - severe heart failure - lung edema - pulmonary infections like tuberculosis, influenca pneumonia, swine influenca - bronchial carcinoma - chemotherapy during last 2 weeks b) in ARDS-patients: -Suspected elevated left arterial pressure - pulmonary infections like tuberculosis, influenca pneumonia, swine influenca - bronchial carcinoma - chemotherapy during last 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ATP-level in BAL-fluid | — |
Secondary
| Measure | Time frame |
|---|---|
| P2R-expression at BALF-cells blood cells | — |
Countries
Germany
Contacts
Public ContactMarco Idzko
Abteilung Pneumologie Universitätsklinikum Freiburg
Outcome results
None listed