severe forms of periodontitisType II chronic periodontitis (K05.1)A localizedB generalizedType III aggressive periodontitisA localizedB generalized K05.1
Conditions
Interventions
Group 1: "Patients with severe periodontitits: epigenetic and functional analyses will be carried out in gingival biopsies"
Group 2: "Periodontitisfree controls: epigenetic and functional analyses wil
Sponsors
Martin-Luther-Universität Halle-Wittenberg
Medizinische Fakultät
Zentrum für Zahn-Mund- und Kieferheilkunde
Universitätspoliklinik für Zahnerhaltungskunde und Parodontologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: unrelated persons Caucasian origin from Central Germany > 18 years old periodontal healthy: - no attachment loss (probing depth = 3.5 mm, no gingival recession due to periodontitis, severe Period: - attachment loss in at least 30% of the teeth with a minimum pocket depth of 4 mm
Exclusion criteria
Exclusion criteria: Pregnancy Therapy with antibiotics within the last 3 month Periodontal therapy within the last 6 month History of diseases associated with periodontitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| "Comparison of DNA methylation pattern in selected cytokine genes in patients with and without periodontitis" | — |
Secondary
| Measure | Time frame |
|---|---|
| "Comparison of mRNA- and protein-expression in selected cytokine genes in patients with and without periodontitis" | — |
Countries
Germany
Contacts
Public ContactSusanne Schulz
Martin-Luther-Universität Halle-Wittenberg Medizinische Fakultät Zentrum für Zahn-Mund- und Kieferheilkunde Universitätspoliklinik für Zahnerhaltungskunde und Parodontologie
Outcome results
None listed