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Influence of individual genetic determination of the BDNF Val66Met polymorphism on plasticity-related sensorimotor recovery after ischemic stroke

Influence of individual genetic determination of the BDNF Val66Met polymorphism on plasticity-related sensorimotor recovery after ischemic stroke

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00003515
Enrollment
80
Registered
2012-01-31
Start date
2012-02-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63

Interventions

Group 1: Target group: Patients with ischemic infarction and a subsequent unilateral sensorimotor impairment of upper limb performance attending standard therapy (OT/PT) and additional application of

Sponsors

Neurologischen Klinik und Poliklinik BG-Universitätsklinikum Bergmannsheil Ruhr-Universität Bochum
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Aged between 40 and 70 years; Right-handedness before the infarction according to the Einburgh Inventory of Handedness; Ischemic infarct (cortical/subcortical) in the coverage area of the middle cerebral artery, according to cranial CT or MRI; Unilateral impairment of sensorimotor performance of upper extremities, i.e. an easy-to-moderate hemiparesis: Grade 3-5 according to MRC; Ability to conduct subtest 1 and 2 of the Jebsen-Taylor Hand Function Test

Exclusion criteria

Exclusion criteria: Lack of knowledge of German language (subjective assessment of the experimenter); Cognitive impairment in accordance DemTect (score 1 + according to MAS); Excessive hand tremor (= 1 in subitem 20; 21 of the UPDRS); Absolute loss of sensorimotor performance of upper extremities (hemi- or paraplegia) and severe paresis (MRC grade 0-2; inability to perform subtest 1 and 2 of the Jebsen-Taylor Hand Function Test); Aphasia, preventing an informed consent; Neglect; Apraxia; Perception threshold of electric stimulation of 20 mA / channel

Design outcomes

Primary

MeasureTime frame
Assessment of sensorimotor performance before and after 10 days of standard rehabilitation (control group). Assessment of sensorimotor performance before and after 10 days of standard rehabilitation and additional daily electrical hand stimulation (control group)

Secondary

MeasureTime frame
Evaluation of the suitability for daily use of the electrical stimulation method (application, comfort). Evaluation of the subjective experience of the patient (performance improvements).

Countries

Germany

Contacts

Public ContactTobias Kalisch

Neural Plasticity Lab Institut für Neuroinformatik Ruhr-Universität Bochum

tobias.kalisch@rub.de+49 (0) 234 3224931

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 7, 2026