Effects of procalcitonin-guided antimicrobial stewardship on reduction of antibiotical use in patients with severe sepsis or septic shock: a retrospective analysis.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003490

Enrollment

150

Registered

2012-02-08

Start date

2010-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41.9 R57.2

Interventions

Group 1: Procalcitonin based algorithmen for tailoring antibiotictherapy. Retrospective analysis from 01.01.2005 to 31.12.2009

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Severe sepsis and septic shock under antibiotic therapy

Exclusion criteria

Exclusion criteria: known pregnancy; bone-marrow transplant or patient under chemotherapy; infections for which long-term antibiotic treatment is strongly recommended (e.g. infective endocarditis, tuberculosis, anterior mediastinitis after cardiac surgery) and do- not-resuscitate orders

Design outcomes

Primary

Measure	Time frame
Retrospective analyses 1. 28-day-Mortality 2. Days on Antibiotictherapy	—

Secondary

Measure	Time frame
1. Lenght of stay in Intensiv Care Unit 2. Ventilation hours 3. Re-infection rate 4. antibiotic cost	—

Countries

Germany

Contacts

Public ContactMarcel Hochreiter

Klinik für Anästhesiologie der Universität Heidelberg

marcel.hochreiter@med.uni-heidelberg.de06221 56 39445

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 23, 2026