Post-KTPL Organ dysfunction - Non-invasive diagnostic with aid of a plasmatic apoptosis marker

Post-KTPL Organ dysfunction - Non-invasive diagnostic with aid of a plasmatic apoptosis marker - CaspAct-KTPL-Study (=Caspase-Activation in Kidney Transplantation)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003483

Enrollment

150

Registered

2012-01-12

Start date

2012-01-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients, undergoing living donor or deceased donor kidney transplantation N18.5

Interventions

Group 1: Patients who underwent living donor kidney transplantation with a malfunction of the graft within the 10-days observation period Group 2: Patients who underwent living donor kidney transplant

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Living donor or deceased donor kidney transplantation

Exclusion criteria

Exclusion criteria: Not meeting the inclusion criteria, refusing study participation, ABO-incompatibility of donor and receipient, highly-immunized patients (PRA>85), preexisting liver insufficiency or liver diseases, other transplantations prior to study participation (KTPL, LTPL, HTPL), taking of immunosuppressive agents prior to study participation (CID)

Design outcomes

Primary

Measure	Time frame
Differences in plasma- and urine concentrations of the different biomarkers in patients following living donor as well as deceased donor kidney transplantation prior to transplantation (Pre), immediately after the surgical procedure (T0), as well as 1 day (T1), 3 days (T3), 5 days (T5), 7 days (T7) and 10 days (T10) later.	—

Secondary

Measure	Time frame
Differences in plasma- and urine concentrations of the different biomarkers prior to transplantation (Pre), immediately after the surgical procedure (T0), as well as 1 day (T1), 3 days (T3), 5 days (T5), 7 days (T7) and 10 days (T10) later, in patients following living donor as well as deceased donor kidney transplantation who developed a malfunction of the graft within the 10-day observation period, in comparison to the related control group without a malfunction.	—

Measure

Time frame

Differences in plasma- and urine concentrations of the different biomarkers prior to transplantation (Pre), immediately after the surgical procedure (T0), as well as 1 day (T1), 3 days (T3), 5 days (T5), 7 days (T7) and 10 days (T10) later, in patients following living donor as well as deceased donor kidney transplantation who developed a malfunction of the graft within the 10-day observation period, in comparison to the related control group without a malfunction.

—

Countries

Germany

Contacts

Public ContactStefan Hofer

Klinik für Anaesthesiologie Uniklinkum Heidelberg

stefan.hofer@med.uni-heidelberg.de06221 5637787

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026