Stress-Coping and Cortisol Analysis in Patients with Non-Syndromic Cleft Lip and Palate: An Explorative Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003466

Enrollment

Registered

2012-01-02

Start date

2010-09-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q35-Q37 F43

Interventions

Group 1: Healthy control group

no significant differences concerning age and gender. 1. Trierer Social Stress Test. Standardized stress test - collection of saliva samples at 7 different time points to determine cortisol dysregulat

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Patients: unilateral cleft lip and palate Controls: healthy control person

Exclusion criteria

Exclusion criteria: acute infections, drug or alcohol abusus, mental illness

Design outcomes

Primary

Measure	Time frame
Seven saliva samples were collected to determine the cortisol level at different time points. The samples were taken at following time points. 2 minutes before the Trier Social Stress Test (TSST). 1, 10, 20, 30, 45 and 60 minutes after the TSST. Cortisol concentration was analyzed by ultra performance liquid chromatography-tandem mass spectrometry.	—

Secondary

Measure	Time frame
The evaluation of stress-coping was performed by "Stressverarbeitungsfragebogen (SVF 120)" first described by Jahnke. Each participant has to complete the questionnaire after the TSST.	—

Countries

Germany

Contacts

Public ContactVolker Gaßling

Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Schleswig-Holstein

gassling@mkg.uni-kiel.de0431597-2791/-2821

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 25, 2026