Combined diffusion tensor imaging (DTI, global fiber tracking and voxel based morphometry (VBM) in patients with idiopathic or atypical Parkinson syndrome

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003454

Enrollment

200

Registered

2012-01-11

Start date

2012-01-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20 G23

Interventions

Group 1: Patients suffering from IPD and atypical Parkinson syndromes like multiple system atrophy, progressive supranuclear palsy, cortico-basal degeneration, or dementia with lewy-bodies. Clinical

Hoehn and Yahr

Non-motor symptoms questionaire (NMS-Quest) and scale (NMS-Scale)

Montreal Cognitive Assessment (MoCA), Beck Depression Inventar (BDI). MRI-sequences: DTI, SWI, resting state, T1 MP-Rage. Group 2: Controls. Clinical Tests: Montreal Cognitive Assessment (MoCA), Bec

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients with parkinson's disease, multiple system atrophy, cortico-basal degeneration, progressive supranuclear palsy or dementia with lewy bodies who are willing to participate at any state of the disease. Controls will be without neurological disease, matched for age.

Exclusion criteria

Exclusion criteria: Contraindications against MRI as huge tatoos, implants as pace makers, impulse generators etc.

Design outcomes

Primary

Measure	Time frame
Detecting the degeneration of the fibre tracts via MRI DTI (diffusion tensor imaging) sequences using global fibre tracking, Comparison of the fibre tracts by voxel based morphometry (VBM), resting-state sequences are performed to test the functionality of these tracts.	—

Countries

Germany

Contacts

Public ContactFlorian Amtage

Neurologische Universitätsklinikum Freiburg

florian.amtage@uniklinik-freiburg.de+49 761 270 50010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026