F10.2
Conditions
Interventions
Group 1: Alcohol dependent patients (according to ICD-10 and DSM-IV, SCID) are scanned with MR-spectroscopy the day of admission to a inpatient detoxification programm and again after 5 and again afte
Sponsors
Zentralinstitut für Seelische Gesundheit
Klinik für Abhängiges Verhalten und Suchtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Legally effective, written informed consent for participation within the study, including ability to communicate with the researchers Alcohol dependent subjects: - Diagnose of alcohol dependence according to ICD-10 and DSM-IV Healthy controls: - no or minimal consumption of alcohol, - laboratory parameters sensitive for alcohol within normal range
Exclusion criteria
Exclusion criteria: Actual psychiatric disorder (Axis I) according to DSM-IV / ICD-10 (assessed with SCID-I) except nicotine abuse or nicotine dependence and alcohol dependence for patients - Positive drugscreen (opiates, cannabinoids, benzodiazepines, barbiturates, cocaine, amphetamine), - actual treatment with psychoactive medication, - MR contraindication (e.g. pacemaker, metallic or electronic implants, metal splinters…) - Severe physical disorders (liver-cirrhosis, severe diabetes), - former psychotic disorder, - actual suicidal tendency or endangerment of others
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentrations of glutamate, glutamine and GABA in the anterior cingulate cortex are assessed with MR-Spectroscopy at the beginning of acute alcohol withdrawal, after fife days of abstinence and after two weeks of abstinence | — |
Secondary
| Measure | Time frame |
|---|---|
| associations of metabolite concentrations in the anterior cingulate cortex at the beginning of acute alcohol withdrawal, after five days of abstinence and after two weeks of abstinence with cue-reactivity to alcoholrelated stimuli. Cue-reactivity will be assessed using functional Magnetic Resonance Imaging (fMRI). | — |
Countries
Germany
Contacts
Public ContactDerik Hermann
Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin
Outcome results
None listed