F10.2
Conditions
Interventions
Group 1: Abstinent alcohol-dependent patients with cue-exposure therapy (CET) (9 therapeutic sessions about 1.5 h)
Group 2: Abstinent alcohol-dependent patients without cue-exposure therapy (CET)
Gro
Sponsors
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Universität
Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: All: Age: between 18 and 65 years Visus > 0.8 Landolt (rings), Appropriate comprehension of the German language, Written informed consent Patients: Alcohol dependent patients according to DSM-IV and ICD-10 criteria will be included after admission to inpatient detoxification and must be abstinent for 5 -21 days when the first assessment takes place.
Exclusion criteria
Exclusion criteria: Axis I mental disorders (SCID-I) except (for patients) abuse and dependence of alcohol and nicotine, neurological disorders, exclusion criteria for MRT (pace maker, implanted metal or pregnancy) positive drug screening, any current psychoactive medication for the last 3 days before study entry, epilepsy, suicidal tendencies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extent of changes of functional and structural connectivity between prefrontal and striatal brain regions caused by the cue-exposure-based extinction training (CET) or neurofeedback as measured by magnetoresonance tomographic methods. Two MRI examinations: Baseline (5 to 21 days after detoxification) and the second three weeks later after the completion of the therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Abstinence of alcohol-dependent patients 3 months after completion of treatment measured by breath test, blood test and Form 90 (Questionnaire) | — |
Countries
Germany
Contacts
Public ContactMartina Kirsch
Klinik für Abhängiges Verhalten und Suchtmedizin, Zentralinstitut für Seelische Gesundheit, Universität Heidelberg
Outcome results
None listed