Lateralization of the analgesic effect of the transcutaneous vagus nerve stimulation (t-VNS®) in human

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00003383

Enrollment

Registered

2011-12-20

Start date

2011-11-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Group 1: verum left - adjustment of the ear electrodes at both sides, left-sided transcutaneous vagus nerve stimulation (t-VNS): frequency 25 Hz, adjust stimulation intensity above perception threshol

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: healthy volunteers healthy in terms of medical history written informed consent form after volunteer information

Exclusion criteria

Exclusion criteria: participation in a clinical trial within the last 4 weeks prior inclusion pregnant or breastfeeding women any medication (except contraceptives) anatomical and pathological abnormalities of the ears indications that the participant is expected not to comply with the clinical investigation plan (e.g. lacking willingness to cooperate)

Design outcomes

Primary

Measure	Time frame
psychophysical measurement of the pressure pain threshold (PPT) at the left and right hand ipsilateral and contralateral to t-VNS time of measurement: befor t-VNS (PRE), during t-VNS (PERI) und after t-VNS (POST)	—

Secondary

Measure	Time frame
psychophysical measurement of the mechanical pain threshold (MPT) and the mechanical pain sensitivity (MPS) at the left and right hand ipsilateral and contralateral to t-VNS measurement of blood pressure and pulse time of measurement: befor t-VNS (PRE), during t-VNS (PERI) und after t-VNS (POST) sensitive sensations (self-evaluation by the volunteer) questionnaire for vegetative symptoms (self-evaluation by the volunteer): assessment of any vegetative changes during measurements (increase/decrease e.g. salivation, lacrimation etc.). number of adverse events / incidents	—

Measure

Time frame

psychophysical measurement of the mechanical pain threshold (MPT) and the mechanical pain sensitivity (MPS) at the left and right hand ipsilateral and contralateral to t-VNS measurement of blood pressure and pulse time of measurement: befor t-VNS (PRE), during t-VNS (PERI) und after t-VNS (POST) sensitive sensations (self-evaluation by the volunteer) questionnaire for vegetative symptoms (self-evaluation by the volunteer): assessment of any vegetative changes during measurements (increase/decrease e.g. salivation, lacrimation etc.). number of adverse events / incidents

—

Countries

Germany

Contacts

Public ContactAndreas Hartlep

cerbomed GmbH

Andreas.hartlep@cerbomed.com+49 9131 9202 76 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026