ATEMWEGSINFEKTANFLLIGKEIT J00 J01 J02 J03 J04 J05 J06 J12 J13 J14 J15 J16 J17 J18 J20 J21 J22
Conditions
Interventions
Group 1: Group of individuals with the 7.5% highest respiratory tract infection scores - these will be asked to provide a saliva sample.
Group 2: Group of individuals with the 40% lowest respiratory t
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Screening study (step 1) 20-70 years of age - comprehension of German language - resident of Freiburg and Breisgau/Hochschwarzwald - consent for participation in questionnaire study. Supplementary study (step 2): same as above - lack of indicated co-morbidities - consent for participation in supplementary study including consent to 1) provide a saliva samples as source of genomic DNA, 2) to allow study nurse to contact participant and primary care physician to validate phenotype - highest 7.5% of RTI score (group 1) - lowest 40% RTI score (group 2).
Exclusion criteria
Exclusion criteria: Screening study: - Residence outside study region - non-comprehension of German language - lack of consent Supplementary study: same as above - prevalence of indicated co-morbidities - lack of consent for supplementary study - RTI score outside range of interest
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the proportion and characteristics of individuals in Germany with frequent and/or severe RTI of unknown cause. | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify genetic susceptibility biomarkers for this phenotype for subsequent prospective validation in independent study populations. | — |
Countries
Germany
Contacts
Public ContactAlexandra Nieters
Centrum für Chronische Immundefizienz, Freiburg
Outcome results
None listed