Young healthy volunteers K05.0
Conditions
Interventions
Group 1: Young healthy volunteers stop their oral hygiene for 21 days. During this period the clinical signs of oral inflammation will be recorded. Parallel blood will be sampled and to detremine infl
Sponsors
Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
18 Years to 25 Years
Inclusion criteria
Inclusion criteria: No history of any systemic disease
Exclusion criteria
Exclusion criteria: Systemic diseases, periodontitis or caries, Medications that interfere with immune response 6 months before the start of the study, pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The systemic concentrations of hsCRP will be determined by immunnephelometrie at day 0, 21 and 42 in serum. | — |
Secondary
| Measure | Time frame |
|---|---|
| The systemic concentration of IL-6, MCP-1 will be measured in vitro by ELISA, for monocyte activation established assays will be used and the microbial diversity as well as the expression of virulence factors will be determined by sequencing techniques. All measurements will be performed at day 0, 21 and 42. | — |
Countries
Germany
Contacts
Public ContactJörg Eberhard
Medizinische Hochschule Hannover
Outcome results
None listed