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Changes in the sense of smell and taste in patients undergoing chemotherapy for head and neck malignancies

Changes in the sense of smell and taste in patients undergoing chemotherapy for head and neck malignancies - chemical senses during chemotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00003361
Enrollment
30
Registered
2011-11-29
Start date
2013-05-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C10.8 C32.8

Interventions

Group 1: The sense of smell and taste is evaluated in all participants before and after each cycle of chemotherapy using the Sniffin´ Sticks test and the whole mouth test.

Sponsors

Hals-, Nasen-, Ohrenheilklinik der Universitätsmedizin Mainz
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Head and neck squamous cell carcinoma, informed consent

Exclusion criteria

Exclusion criteria: Olfactory disorders as a result of a chronic rhinosinusitis, head trauma, neurodegenerative disease, inability to give informed consent

Design outcomes

Primary

MeasureTime frame
Changes in the TDI-score are measured before and after each cyclus of chemotherapy using the Sniffin´ Sticks test.—

Secondary

MeasureTime frame
Change in subscores (threshold, discrimination, identification) are measured before and after each cyclus of chemotherapy using the Sniffin´ Sticks test. Changes in the sense of taste are measure before and after each cyclus of chemotherapy using the whole mouth test. The influence of age, gender, smoking habits and duration of therapy on the results are investigated in the model.—

Countries

Germany

Contacts

Public ContactBoris Haxel

Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- Hals-Chirurgie der Universitätsmedizin der Johannes Gutenberg Universität Mainz

haxel@hno.klinik.uni-mainz.de06131177361

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026