Dysfunctional neuronal networks in alcoholism: Utilizing translational neuroimaging to identify altered brain connectivity and treatment efficacy predictors

Dysfunctional neuronal networks in alcoholism: Utilizing translational neuroimaging to identify altered brain connectivity and treatment efficacy predictors - Transalc

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003357

Enrollment

270

Registered

2011-11-29

Start date

2011-12-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F10.2

Interventions

Group 1: alcohol dependent patients with anticraving medication (Naltrexone or Acamprosate) Group 2: alcohol dependent patients without anticraving medication Group 3: healthy controlls

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: alcohol dependence (DSM IV; ICD 10) and average84g of pure alcohol per day during the last 90 days

Exclusion criteria

Exclusion criteria: other Axis 1 psychiatric diagnoses than alcohol- or nicotine-dependence in the last 12 months, common exclusion criteria for MRI, positive urine drug screen, severe medical illness and history of brain injury

Design outcomes

Primary

Measure	Time frame
To determine differences in functional connectivity between alcohol addicted patients and healthy controls using rsfMRI and DTI	—

Secondary

Measure	Time frame
To determine differences in functional connectivity between alcohol addicted patients treated with Naltrexone or Acamprosate vs. alcohol addicted patients without medication using rsfMRI and DTI	—

Countries

Canada, Germany

Contacts

Public ContactDerik Hermann

Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin

derik.hermann@zi-mannheim.de0621/17033541

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026