F10.2
Conditions
Interventions
Group 1: alcohol dependent subjects are scanned with MR-Spectroscopy at the beginning of alcohol withdrawal and after 14 days of controlled abstinence. At both times blood samples are collected for ge
Sponsors
Zentralinstitut für Seelische Gesundheit
Klinik für Abhängiges Verhalten und Suchtmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Men and women aged 18 to 65 - Legally effective, written informed consent for participation within the study Alcohol dependent subjects: - Diagnose of alcohol dependence according to ICD-10 and DSM-IV Healthy controls: - no or minimal consumption of alcohol, - laboratory parameters sensitive for alcohol within normal range,
Exclusion criteria
Exclusion criteria: - Actual psychiatric disorder (Axis I) according to DSM-IV / ICD-10 (assessed with SCID-I) except nicotine abuse or nicotine dependence and alcohol dependence for patients - Positive drugscreen (opiates, cannabinoids, benzodiazepines, barbiturates, cocaine, amphetamine), - actual treatment with psychoactive medication, - MR contraindication (e.g. pacemaker, metallic or electronic implants, metal splinters…) - Severe physical disorders (liver-cirrhosis, severe diabetes), - former psychotic disorder, - actual suicidal tendency or endangerment of others
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of glutamate in the anterior cingulate cortex is assessed with MR-Spectroscopy at the beginning of acute alcohol withdrawal and after two weeks of abstinence | — |
Secondary
| Measure | Time frame |
|---|---|
| genetic associations of glutamate concentration in the anterior cingulate cortex at the beginning of acute alcohol withdrawal and after two weeks of abstinence. Genes and genexpression are assessed via blood samples. | — |
Countries
Germany
Contacts
Public ContactDerik Hermann
Zentralinstitut für Seelische Gesundheit Klinik für Abhängiges Verhalten und Suchtmedizin
Outcome results
None listed