F10.2
Conditions
Interventions
Group 1: alcohol-dependent patients (currently abstinent) will be investigated using functional magnetic resonance imaging (fMRI) und genetic analysis
Group 2: healthy control subjects will be investi
Sponsors
Charité Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Healthy Controls - men and women, aged 18 to 75 - legally effective, written informed consent for participation within the study - right handedness - no psychiatric disorder according to ICD 10 - no psychotropic substances within the last 7 days Alcohol-depdent patients - men and women, aged 18 to 75 - legally effective, written informed consent for participation within the study - right handedness - no other psychiatric disorder according to ICD 10 - no psychotropic substances within the last 7 days
Exclusion criteria
Exclusion criteria: - physical disorders, which might interfere with the planned examination (z.B. cerebro-organic disorder) - MR-contraindication (z.B. pace maker, metalic or electronic implants, metal splinters, Operationsklammern) - anamnestic manifeste psychiatric axis I disorder and/or axis II according to ICD-10 except alcohol dependence for patients - medication or drug dependence - medication or drug abuse (randomisized urin testing) - insufficient knowledge of German language - claustrophobia - for women: pregnancy (exclusion via pregnancy test)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the present multicenter study in Berlin, Bonn and Mannheim is to use fMRI in alcohol addiction for endophenotyping in order to study the relevance of genetic variation, in particular in dopaminergic and glutamatergic genes, for addiction. | — |
Secondary
| Measure | Time frame |
|---|---|
| test the impact of genetic variation (within important candidate genes for alcohol dependence using genetic analysis) on activation of the mesolimbic system in alcohol-dependent patients and healthy controls (measured with fMRI) and test their predictive effects for treatment outcome in alcoholics (assessed during 6 months follow-up period) | — |
Countries
Germany
Contacts
Public ContactKatrin Charlet
Klinik für Psychiatrie und Psychotherapie CCM Charité - Universitätsmedizin Berlin
Outcome results
None listed