acute epididymitis N45
Conditions
Interventions
Group 1: Therapy according to the guidelines
Sponsors
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Male, at least 18 years of age - Suffer acute epididymitis, defined as a) enlarged epididymis and b) epididymal hypervascularity in ultrasonography
Exclusion criteria
Exclusion criteria: - Testicular torsion - Other primary scrotal diseases than epididymo-orchitis - Any condition that, in the opinion of the investigator, would comprise the study NOTE: Subjects may be enrolled in this study regardless of whether previous antimicrobial therapy was initiated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •investigate the etiology of acute epididymo-orchitis (bacterial and viral investigation of urine, p.r.n. blood, semen, testicular and epididymal tissue) | — |
Secondary
| Measure | Time frame |
|---|---|
| • determine the pathogen in correspondence to sexual activity/age (IIEF-questionnaire) • determine systemic inflammatory parameters (CRP, White blood cell count, procalcitonin, cytokines) • Documentation of markers for testicular cancer (AFP, HCG, LDH) • determine the impact on seminal parameters and sperm (semen analysis according to WHO 1999 and WHO 2010) • determine inflammatory parameters in the male genitourinary tract (2 resp. 4-glas test, leukocytes in urine, PSA in blood, inflammatory parameters in sement: leukocytes, elastase, cytokines) • determine the impact on fertility (semen analysis and future paternity) • determine comorbidities associated with acute epididymo-orchitis (anamnesis, clinical investigation, laboratory parameters, medical reports) • determine the impact of analgetic and antimicrobial premedication on the clinical course (documentation of type and duration of premedication) • determine the impact of previous antimicrobial therapy on the etiology • determine the interval between onset of symptoms and seeking medical help • determine ultrasonographic features associated with acute epididymo-orchitis • (testicular size, epididymal size, perfusion oft he spermatic cord, testis and epididymis, concomitant hydrocele, abscess formation). • determine a possible side-specific distribution • determine urinary flow parameters and bladder function (uroflowmetry, residual urine, urodynamic bladder investigation, IPSS questionnaire) • determine the impact of the infection on quality of life using questionnaires (NIH-CPSI, CESI) • determine the need for surgical intervention • determine risk factors to suffer epididymo-orchitis • determine percentage of patients with epididymitis and epididymo-orchitis (clinical and ultrasound assessment) • determine the clinical course (ambulatory visits, follow-up by telephone) • determine the benefit of 16 S rRNA gene sequencing • determine the possibility of recurrent and the development of chronic epididymo-orchiti | — |
Countries
Germany
Contacts
Public ContactAdrian Pilatz
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen
Outcome results
None listed