Respiratory muscle impairment in patients with Systemic Sclerosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003311

Enrollment

Registered

2011-10-25

Start date

2011-10-25

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M34

Interventions

Group 1: Patients with Systemic Sclerosis: Measurement of respiratory muscle strength by twitch mouth pressure (TwPmo), twitch transdiaphragmatic pressure (TwPdi), maximal inspiratory pressure (PImax)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients: - Systemic Sclerosis according to the ACR-Criteria Controls: - normal lung function

Exclusion criteria

Exclusion criteria: neuromuscular diseases, thoracic deformity, COPD, respiratory infections, pregnancy, obstructive sleep apnea, cardiac pacemaker, AICD, electric / metal implants in head and neck area

Design outcomes

Primary

Measure	Time frame
Difference in TwPmo (twitch mouth pressure) in patients with Systemic Sclerosis compared to healthy subjects. Method: Twitch mouth pressure assessment during bilateral anterior magnetic stimulation of the phrenic nerves (Kabitz et. al Respir Physiol Neurobiol. 2007 Jun 15;156(3):276-82.)	—

Secondary

Measure	Time frame
Difference in other parameters of respiratory muscle strength in patients with Systemic Sclerosis compared to healthy subjects (i.e. PImax (maximal inspiratory pressure), SnPna (Sniff Pressure ), P0.1, TwPdi (twitch transdiaphragmatic pressure)). Assessment of these parameters are in accordance with international guidelines (ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624.).	—

Measure

Time frame

Difference in other parameters of respiratory muscle strength in patients with Systemic Sclerosis compared to healthy subjects (i.e. PImax (maximal inspiratory pressure), SnPna (Sniff Pressure ), P0.1, TwPdi (twitch transdiaphragmatic pressure)). Assessment of these parameters are in accordance with international guidelines (ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624.).

—

Countries

Germany

Contacts

Public ContactDavid Walker

Abteilung Pneumologie

david.walker@uniklinik-freiburg.de07612703706

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026