Identification of biomarkers, functional parameters and clinical risk factors predisposing for the development of pulmonary chronic GVHD after allogeneic hematopoietic stem cell transplantation.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003304

Enrollment

250

Registered

2011-11-02

Start date

2011-12-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obliterative bronchiolitis, bronchiolitis obliterans with organizing pneumonia (BOOP), non-classifiable interstitial pneumonia (NCIP) chronic GVHD, ICD-10: T86.05, T86.06, T86.07 T86.06 T86.06

Interventions

Group 1: Hematopoietic stem cell recipients with chronic GVHD. Regular measurement of serological, cytogenetic, molecular and cellular markers in the blood. Pulmonary function tests, radiological test

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: free of relapse after allogeneic HSCT

Exclusion criteria

Exclusion criteria: relapse

Design outcomes

Primary

Measure	Time frame
Incidence rates of obliterative bronchiolitis (BO), bronchiolitis obliterans with organizing pneumonia (BOOP), non-classifiable interstitial pneumonia (NCIP). Correlation with clinical risk factors and Biomarkers (TIM-1a, Elafin, BAF, NFkappaB, TGFbeta, HIF1a, Il-17, FoxP3, INOS, IDO, TLR-2, TLR-9, Wnt/beta-catenin, sIl-2, T-regs)	—

Secondary

Measure	Time frame
Incidence rates of chronic GVHD. Correlation with clinical risk factors and Biomarkers (TIM-1a, Elafin, BAF, NFkappaB, TGFbeta, HIF1a, Il-17, FoxP3, INOS, IDO, TLR-2, TLR-9, Wnt/beta-catenin, sIl-2, T-regs)	—

Countries

Germany

Contacts

Public ContactMarkus Ditschkowski

Westdeutsches Tumorzentrum Klinik für Knochenmarktransplantation Universitätsklinikum Essen

markus.ditschkowski@uk-essen.de0201-723-3136

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026