Morphometric correlates and predictors of impaired gait and balance in Parkinson’s Disease-a pilot study

Morphometric correlates and predictors of impaired gait and balance in Parkinson’s Disease-a pilot study - KLI82-B00

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003290

Enrollment

100

Registered

2011-10-05

Start date

2011-11-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20

Interventions

Group 1: Patients with Parkinson's disease without gait- and/or balancedisturbances. An MRI examination with 3.0 Tesla will be done in each participant. Furthermore a clinical examination of gait, bal

Eligibility

Sex/Gender

All

Age

40 Years to 85 Years

Inclusion criteria

Inclusion criteria: A) Inclusion criteria patients: 1) the subject is aged between 40 and 85 years; 2) clinical diagnosis of PD obtained by a neurologist according to published clinical diagnostic criteria; 3) the patient has the ability to communicate well with the investigator and comply with the requirements of the study; 4) written informed consent is obtained. B) Inclusion criteria healthy controls: 1) the subject is aged between 40 and 85 years; 2) written informed consent is obtained. 3) The subject has the ability to communicate well with the investigator and comply with the requirements of the entire study

Exclusion criteria

Exclusion criteria: BA Exclusion criteria patients: 1) History of other neurological or psychiatric disorders or conditions; 2) The subject has a history of alcohol, narcotic, or any other drug abuse as defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, 4th Edition (DSM IV). 3) the subject is pregnant. 4) the subject is unsuitable for an MRI study (e.g. Pacemakers; medical or bio-stimulation implants which are contraindicated for MRI scans and which may include vagus nerve stimulators, implantable cardioverter-defibrillators, loop recorders, insulin pumps, cochlear implants) B) Exclusion criteria healthy controls: 1) History of neurological or psychiatric disorders or conditions; 2) The subject has a history of alcohol, narcotic, or any other drug abuse as defined by the Diagnostic and Statistical Manual of the American Psychiatric Association, 4th Edition (DSM IV). 3) the subject is pregnant. 4) the subject is unsuitable for an MRI study (e.g. Pacemakers; medical or bio-stimulation implants which are contraindicated for MRI scans and which may include vagus nerve stimulators, implantable cardioverter-defibrillators, loop recorders, insulin pumps, cochlear implants).

Design outcomes

Primary

Measure	Time frame
Evaluation of morphometric correlates and predictors of impaired gait and balance in Parkinson’s Disease in 3.0 Tela MRI.	—

Secondary

Measure	Time frame
The aims of this study are (i) to assess changes occurring in patients with PD compared to healthy controls, (ii) to discriminate patients with PD from healthy controls and (iii) to assess changes occurring in patients with the PIGD subtype of PD compared to PD patients presenting with a non-PIGD subtype (iv) to determine progression of morphometric MR-indices using multimodal MRI sensitive to complementary tissue characteristics.	—

Measure

Time frame

The aims of this study are (i) to assess changes occurring in patients with PD compared to healthy controls, (ii) to discriminate patients with PD from healthy controls and (iii) to assess changes occurring in patients with the PIGD subtype of PD compared to PD patients presenting with a non-PIGD subtype (iv) to determine progression of morphometric MR-indices using multimodal MRI sensitive to complementary tissue characteristics.

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Countries

Austria

Contacts

Public ContactAnna Hussl

Medizinische Universität Innsbruck Universitätsklinik für Neurologie

anna-christina.hussl@i-med.ac.at

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026