Healthy Volunteer F60.3
Conditions
Interventions
Group 1: Patients
To test the hypothesis dyads of participants will be studied. Participants will participate in three different paradigms:
1. A basic emotion processing paradigm.
2. A simple shared
Sponsors
Zentralinsitut für Seelische Gesundheit
Eligibility
Sex/Gender
Female
Age
19 Years to 60 Years
Inclusion criteria
Inclusion criteria: - Sufficent knowlege of german language -Able to give informed conset For patients: Borderline personality disordr according to DSM IV
Exclusion criteria
Exclusion criteria: - MR excllusion criteria (metal parts in body, brain surgery, permanent make up) - pathological gambling For controls: - any psychiatric disoder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome will be the analysis of fMRI data. Thereby the aim is to identify brain regions with emotional processing (paradigm 1) joint attention (paradigm 2) and trust of fairness (paradigm 3). Hyperscanning will be conducted on two identical Siemens 3 Tesla Trio scanners at the Central Institute of Mental Health. Data sets will be analyzed stepwise. First, preprocessing of the data will proceed using our standard published techniques and the software package SPM8. Second, the data will be analyzed separately using the general linear model and statistical parametric mapping (again in SPM8). Thereby the aforementioned brain regions in association with the paradigms are aimed to be identified. For this, a general linear model to the data sets, using our experimental events as predictors, is applied. Contrast images from each subject will then be introduced to a second level group analysis to test for group differences. These contrast groups can also be used to investigate correlations between individual brain activation and behavioral or oxytocin data (see Secondary Outcome). Third, the focus of the experiment is the characterization of interpersonal neural systems supporting dyadic interaction across both brains simultaneously. This is a current research frontier in neuroimaging data analysis, so three new approaches will be explored. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures can be classified in 1. behavioral data , 2. Oxytocin measurements and 3. emotional state data. 1. Behavioral Data For the matching task, reaction times can be used to quantify processing speed. For the joint attention task, reaction times are a relevant behavioral readout of the efficacy of cooperation. In the trust game, a detailed analysis of the investment and repayment time courses has been provided by King-Casas et al. (King-Casas et al., 2008), which we will follow in this hyperscanning experiment to provide measures of trust, cooperation and perceived fairness over the course of the game. 2. Oxytocin Measurements Before the scanning sessions, subjects will give an urine sample for measurement of Oxcytocin. 3. Emotional state data Participants' current emotional states, both before and after each of the scanning sessions, will be assessed with the state versions of the State- Trait Anger Expression Inventory (STAXI-S) (Spielberger, 1988) and State-Trait Anxiety Inventory (STAI-S) (Spielberger et al., 1983) to determine potential effects of vasopressin on current levels of anger and anxiety, respectively. Valence, arousal, and dominance will also be assessed before and after the scanning sessions using the Self-Assessment Manikin (Bradley& Lang, 1994). | — |
Countries
Germany
Contacts
Public ContactPeter Kirsch
Zentralinstitut für Seelische Gesundheit
Outcome results
None listed