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Neurobiological and psychological reaction patterns on social exclusion in borderline personality disorder

Neurobiological and psychological reaction patterns on social exclusion in borderline personality disorder

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00003275
Enrollment
280
Registered
2016-03-02
Start date
2012-07-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F60.31 F43.1

Interventions

Group 1: 80 Patients with current Borderliner Personality Disorder (thereof 20 in the age between 15 and 17): Induction of social exclusion via Mannheim Group Rejection Paradigm (MGRP). Assessment of

Sponsors

Zentralinstitut für Seelische Gesundheit Klinik für Psychosomatik und Psychotherapeutische Medizin
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Diagnosis of BPD or remitted BPD or PTSD after childhood sexual abuse or healthy control without any psychiatric illness

Exclusion criteria

Exclusion criteria: Pregnancy, schizophrenia, bipolar-I disorder, substance abuse within the last two years, major depression (MD), organic brain disease, history of epilepsy, brain trauma, brain tumor, or other significant neurological or medical condition, psychotropic medication within the last two weeks

Design outcomes

Secondary

MeasureTime frame
Relation between the willingness to cooperate and aggression after social exclusion and rejection sensitivity (assessed with the RSQ-questionnaire) and self-esteem (assess with the Rosenberg self-esteem-scale)

Primary

MeasureTime frame
Willingness to cooperate and aggressive behavior is assessed via a combination of PSAP („Point Substraction Aggression Paradigm“) and a trust-game after the induction of social exclusion. Aggressiveness is additionally assessed with a self-rating questionnaire (STAXI- State Trait Anger Expression Inventory) before and after the induction of social exclusion.

Countries

Germany

Contacts

Public ContactMelanie Domsalla

Zentralinstitut für Seelische Gesundheit Klinik für Psychosomatik und Psychotherapeutische Medizin

melanie.domsalla@zi-mannheim.de0621 1703 4417

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026