Contribution of the cerebellum to tremor generation and frequency modulation in resting and postural tremor: an rTMS study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00003267

Enrollment

Registered

2011-09-14

Start date

2014-04-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G25.0 G20.10 G25.2

Interventions

Group 1: Every subject included in this study will be investigated by rTMS using theta-burst stimulation (3 pulses with 50 Hz every 200 ms over 40 seconds, all together 600 stimuli) at 80 - 120 % of

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients presenting a continuous Parkinsonian resting or postural tremor, essential tremor, Holmes tremor or cerebellar Tremor

Exclusion criteria

Exclusion criteria: Seizures, implants consisting metal, cardiac defibrillator, implants of the inner ear, pumps containing medication, alcohol and drug addiction, other psychiatric diseases (esp. depression).

Design outcomes

Primary

Measure	Time frame
Tremor analysis is used to quantify the tremor amplitude and frequency. A comparison of tremor amplitude and frequency before and after the rTMS intervention, we can analyze if a frequency modulation had taken place and if a reduction of tremor amplitude occurs.	—

Countries

Germany

Contacts

Public ContactFlorian Amtage

Neurologische Universitätsklinikum Freiburg

florian.amtage@uniklinik-freiburg.de+49 761 270 50010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026