healthy voluteers subjected to hypobaric hypoxic conditions
Conditions
Interventions
Group 1: placebo
Group 2: 800 I.E. vitamin E, 1000 mg vitamin C, 200,000 I.E. vitamin A, 600 mg N-acetylcysteine in the form of a one single tablet po per day commencing 2 months prior until completio
Sponsors
Inselspital Bern
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: adult, healthy, well-trained mountaineers with previous trekking experience and basic mountaineering skills
Exclusion criteria
Exclusion criteria: any type of cardiac, renal, hepatic or respiratory diseases or acute or chronic infectious or inflammatory disease, presence of any metabolic disorder, regular intake of medications, and the development of high-altitude pulmonary edema or high-altitude cerebral edema after rapid ascent to altitudes below 3500 m
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in mitochondrial function of peripheral blood monocytes measured as activity of citrate synthase using a citrate synthase assay kit (Sigma-Aldrich, CS0720) and activity of cytochrome c oxidase using a cytochrome c oxidase assay kit (Sigma-Aldrich, CYTOCOX1) on the altitudes of 440m (baseline), 3700m (day 1), 4500m (day 4) and 5400m (day 9 ) of the expedition. | — |
Countries
Switzerland
Contacts
Public ContactTobias Merz
Inselspital Bern
Outcome results
None listed