deep brain stimulation in patients with refractory epilepsy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00003148

Enrollment

Registered

2011-07-04

Start date

2011-06-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G40.2

Interventions

Group 1: 3 months baseline implantation of deep brain stimulation electrodes one month without stimulation three months stimulation of ncl. accumbens five months without stimulation open label period

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: pharmaco-refractary partial epilepsy with at least three disabling seizures in four week during the past three months

Exclusion criteria

Exclusion criteria: psychiatric and/or internal relevant comorbidity, psychogenic non-epileptic seizures, progressive degenerative neurological disease, custodial guardianship

Design outcomes

Primary

Measure	Time frame
Fraction of patients with at least 50% reduction of seizure-frequency after three months of deep brain stimulation in comparison with the untreated controls.	—

Secondary

Measure	Time frame
Change of seizure severity assessed with the Liverpool Seizure Severity Scale (assessment: at enrolment, after 3 month, 1 month post-implantation, 4 month post-implantation, 5 month post-implantation, 8 month post-omplantation, 9 month post-implantation, 12 month post-implantation)	—

Countries

Germany

Contacts

Public ContactAlexander Kowski

Charité - Universitätsmedizin Berlin

neurostimulation-epilepsie@charite.de, epilepsie@charite.de030 450 560 003

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026