Deep brain stimulation in idiopathic dystonia: clinical characterisation of a cohort of patients with therapeutic failure of GPi-DBS

Deep brain stimulation in idiopathic dystonia: clinical characterisation of a cohort of patients with therapeutic failure of GPi-DBS - GPi-DBS-failure

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00003105

Enrollment

Registered

2011-07-11

Start date

2010-10-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

insufficient response to deep brain stimulation of the internal part of the globus pallidus G24.1

Interventions

Group 1: cross-sectional study in a cohort of 26 patients with GPi-DBS and insufficient therapeutic response to GPi-DBS clinical examination and characterisation of cohort

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: - age between 18-85 years - diagnosis of idiopathic dystonia at time of surgery - bilateral GPI-DBS - poor response to GPI-DBS (less than 30 % improvement on the BFMDRS-M compared to preoperative state) - stable clinical status after GPi-DBS for a minimum of 3 months - written informed consent given by patient - no other severe neurological or other clinical problem

Exclusion criteria

Exclusion criteria: - other severe neurological disease (dementia, epilepsy) - persons who are not legally competent, minors and indivduals who have been under custody due to a court ruling or by decision of public authorities

Design outcomes

Primary

Measure	Time frame
cross-sectional study: examination of patients with poor therapeutic response to GPi-DBS (Globus Pallidus internus- deep brain stimulation), clinical characterisation of this patient cohort with re-evaluation of initial diagnosis at time of surgery, classification into groups with putative causes of therapeutic failure, evaluation of frequencies of symptoms and findings in this cohort	—

Countries

Germany

Contacts

Public ContactAmande Pauls

Neurologie, Uniklinik Köln

amande.pauls@uk-koeln.de0221-47897818

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026