A European treatment protocol for bonesarcoma in patients older than 40 years (EURO-B.O.S.S.)

A European treatment protocol for bonesarcoma in patients older than 40 years (EURO-B.O.S.S.) - Euro-B.O.S.S.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000942

Enrollment

135

Registered

2015-03-19

Start date

2009-11-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C40

Interventions

Group 1: Standard therapy of approved drugs in osteosarcoma patients aged more than 40 years.

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Histologically proven diagnosis of high-grade sarcoma of bone of any site. 2. Histologic types: osteosarcoma (high-grade surface, central primary and secondary), fibrosarcoma, malignant fibrous histiocytoma, leiomyosarcoma, dedifferentiated chondrosarcoma, angiosarcoma. EUROpean Bone Over 40 Sarcoma Study EURO-B.O.S.S. Version_2.0 COSS Dec 2009 13/24 3. Age: 41 - 65 4. Normal bone marrow, hepatic, cardiac and renal function 5. Absence of contraindications to the use of cisplatin, adriamycin (doxorubicin), and ifosfamide 6. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Planned chemotherapy and/or follow-up not feasible 2. Previous chemotherapy treatment, which contraindicates the use of one or more drugs, included in the present procol 3. Previous chemotherapy treatment for the current tumor 4. White blood count 2 times the normal values 8. ECOG performance status > 2 9. Chondrosarcoma or small/round cell bone sarcoma including mesenchymal chondrosarcoma and Ewing’s family tumors. 10. Pregnancy

Design outcomes

Primary

Measure	Time frame
overall survival	—

Secondary

Measure	Time frame
chemotherapy-related toxicity, the event free survival, and the histologic response to preoperative chemotherapy.	—

Countries

Germany, Italy, Sweden

Contacts

Public ContactStefan Bielack

Klinik Stuttgart

st.bielack@olgahospital.de+49 711 992-2461

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026