N18.8 Z94.0
Conditions
Interventions
Group 1: 15 well-selected immunologically low-risk patients receive a minimized immunsuppressive regime after kidney transplantation. The immunsupression starts with antithymocyte globin
induction fol
Sponsors
Universitätsklinikum Freiburg
Klinik für Allgemein und Vizeralchirurgie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - first kidney transplantation - ager 18 - 65 years - Written informed consent - Highly effective contraception
Exclusion criteria
Exclusion criteria: - slave- or multi-transplantation - combined transplantation - age 300 mg/dl, triglycerides > 400 mg/dl) - Epstein-Barr-virus IgG negative - chronic hepatitis B and hepatitis C infection - thrombocytopenia < 50.000 tsd/µl -coagulopathies ( lack of or a defect in v. Willebrand factor, hemophilia, lack of protein S lack of protein C )
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transplant function (serum creatinine mg/dl and ceatinin-clearance) after 1, 3, 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| • patient- and transplant survival • rate and degree of acute bioptic confirmed graft shedding(after Banff) and number of steroid-resistant sheddings • intake of calcineurin-inhibitors • steroid long-term medication • incidence of Chronic Allograft Nephropathy (CAN) • level of blodd pressure and antihypertensive medication • lipid level and lipid reducing medication • liver function • rate and degree of oppertunistic infections • incidence of an haematological adverse effect • incidence of malignant disease | — |
Countries
Germany
Contacts
Public ContactOliver Thomusch
Abt. Allgemein- und Viszeralchirurgie
Outcome results
None listed