C22.0 K73.9
Conditions
Interventions
Group 1: observation group: patients with cronic hcv- infection without cirrhosis of the liver and without HCC (10 patients)
Group 2: observation group: patients with hcv- infection with cirrhosis of
Sponsors
UKL Freiburg, Med. Klinik II
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: a) patients with chronic hepatitis c- infection: no cirrhosis of the liver (= Desmet IV), no HCC - suspected lesion in the liver b) patients with hcv- associated cirrhosis of the liver: - cirrhosis of the liver confirmed by ultrasound, CT/MRI imaging or biopsy, all child - stages c) patients with hcv- associated HCC: diagnosis of HCC according to the AASLD criteria, HCC has not been treated at the time of enrollment, all BCLC- /UICC- stages. d) for all three groups: diagnosis of the chronic hcv- infection with virus rna and serologic parameters (anti-hcv) and abnormal liver function for more than 6 months, no antiviral treatment during the last 6 months
Exclusion criteria
Exclusion criteria: - application of dietary supplements - excessive alcohol consumption - all other etiologies leading to a liver injury - patients with an acute-phase- reaction (SIRS, sepsis, patients in intensive care units) - extrahepatic neoplasm - rheumatic disease apart from hcv- associated immunologic phenomena - diabetes mellitus I and II - immunological diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| comparison of the selenium levels in these 4 groups | — |
Secondary
| Measure | Time frame |
|---|---|
| - selenium levels and inflammatory activity - selenium levels and stadium of HCC - selenium levels and MELD(Na)score | — |
Countries
Germany
Contacts
Public ContactHans Christian Spangenberg
UKL Freiburg, Med. Klinik II
Outcome results
None listed