I25.13
Conditions
Interventions
Group 1: Blodd samples are taken in all patients 4-6 and 18-24 hours after stress echocardiography, in which EMP levels are determined by FACS (fluorescence-activated cell sorting).
Sponsors
Medizinische Klinik und Poliklinik II
Universitätsklinikum Bonn
Rheinische Friedrich-Wilhelms-Universität
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age =18 years, patients with proven coronary artery disease (CAD) or suspected CAD undergoing stress echocardiography before coronary angiography, written informed consent.
Exclusion criteria
Exclusion criteria: Age <18 years, acute coronary syndrome (STEMI, NSTEMI, unstable angina), severe heart valve defects, previous coronary artery bypass grafting, ineligibility for adequate echocardiography, contraindications for stress test (severe aortic stenosis, unstable angina, malignant arrhythmia, severe HOCM), pregnancy, mental disorders, decompensated heart failure (NYHA III and IV), allergy against contrast dye, hyperthyroidism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase of microparticle level 4-6 and 18-24 hours after stress echocardiography determined by FACS (fluorescence-activated cell sorting) and association with myocardial ischemia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of different microparticle subtypes (endothelial versus thrombocyte origin) for the prediction of ischemia. Relevance of microparticle level for the prediction of future major adverse cardiovascular and cerebral events (MACCE: cardiovascular death, myocardial infarction, stroke, target lesion revascularization) | — |
Countries
Germany
Contacts
Public ContactJan-Malte Sinning
Medizinische Klinik und Poliklinik II Universitätsklinikum Bonn Rheinische Friedrich-Wilhelms-Universität
Outcome results
None listed