A41 R57.2 K72.7
Conditions
Interventions
Group 1: No interventions, solely the observation of the following parameters in septic patients (Number = 120):
Measurements will take place at the time of ICU discharge (with only a subgroup of 20
Sponsors
Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Common inclusion criteria (all participants): Minimum age: 18; informed consent, sufficient skills in German language; Sepsis specific: Maximum age: 85, survivors of severe sepsis/ septic shock; duration of mechanical ventilation = 3 days in ICU; non septic ICU patients: Maximum age: 85;duration of mechanical ventilation = 3 days in ICU; HE sepcific: Maximum age: 65; confirmed diagnosis of liver failure (sonographic, CT, histological); HE-grade 0-2, Control specific: Maximum Age for neurological examinations: 65 and 85 years for pain examinations
Exclusion criteria
Exclusion criteria: common exclusion criteria (for all participants): Participation in a different study; confirmed diagnosis of dementia or other severe neurological disorder (epilepsy included); seizure, confirmed septic shock or severe sepsis in anamnesis; recent drug abuse and/ or alcohol intoxication sepsis specific: medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder; additionally for neurological examinations (25 patients): Medication with neuroleptics, sedatives, antidepressants, Amaurosis non-septic ICU patients: ICU stay due to sepsis or septic shock; medication with analgetics; Amputation of upper limbs; confirmed chronic or other neuropathic pain disorder; HE-specific: Medication with neuroleptics, sedatives, antidepressants, Amaurosis; life expectancy < 1 year; spontaneous bacterial peritonitis; actual delir and/ or deprivation; liver transplantation control specific: medication with analgetics, amputation of the upper limbs; confirmed confirmed chronic or other neuropathic pain disorder; medication with neuroleptics, sedatives, antidepressants, Amaurosis; MEG and MRI-sepcific: pace maker and other magnetic implants; claustrophobics; pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary goals (12 month after ICU discharge): a)evaluation of chronic pain, functional impairment and the quality of life in former septic patients in comparison to non-septic ICU patients and healty controls b)Identifications of neurophysiological mechanisms and behavioural correlates after severe sepsis/ septic shock | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary goals (range from discharge up to 24 months after discharge) a) assessment of neurophysiological characteristics of pain processing by means of quantitative sensory testing (QST) and the laser - stimulation of Ad- and C-Fibers at the time of ICU discharge, as well as 6, 12 ad 24 months after ICU discharge b) identification of neurophysiological differences/ similarities of sepsis survivors and patients with hepatic encephalopathy | — |
Countries
Germany
Contacts
Public ContactAlbrecht Günther
Hans-Berger-Klinik für Neurologie Universitätsklinikum der FSU Jena
Outcome results
None listed