molecular MRI in knee osteoarthritis: application and validation of biochemically sensitive MRI-sequences

molecular MRI in knee osteoarthritis: application and validation of biochemically sensitive MRI-sequences - KORdGEMRIC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000729

Enrollment

Registered

2011-02-21

Start date

2011-06-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M17.1

Interventions

Group 1: Observation group: 40 Patients who are planned to receive a total knee replacement. X-rays according to the house standard. Measuring of x-ray parameters (grade of osteoarthritis, minimal joi

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients, who are diagnosed with a knee osteoarthritis and are planned to receive a total knee replacement.

Exclusion criteria

Exclusion criteria: no written consent after information; technical implants, metal fragments; non-removable decoration; claustrophobia; cannot ly down for a long time including lung dysfunction or reflux; pregnancy; breast feeding mother; allergic reaction to contrast agent; allergic asthma; renal dysfunction - to be demonstrated in a creatinin-value within normal range; liver dysfunction; acute or chronic infections, epilepsia, brain disease, tumors.

Design outcomes

Primary

Measure	Time frame
Hypothesis: cartilage degeneration can be demonstrated with the aid of molecular cartilage MRI. Changes can be reproduced histologically	—

Secondary

Measure	Time frame
no secondary outcome	—

Countries

Germany

Contacts

Public ContactChristoph Zilkens

Orthopädische Klinik Universitätsklinikum Düsseldorf

christoph.zilkens@med.uni-duesseldorf.de0211-8117964

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 5, 2026