Obstructive sleep apnea (OSA) postoperative risk stratification trial

Obstructive sleep apnea (OSA) postoperative risk stratification trial - OSARST

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000704

Enrollment

200

Registered

2011-01-27

Start date

2011-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G47.3

Interventions

Group 1: Observational group 1: Patients with OSA undergoing elective coronary bypass surgery. Group 2: Observational group 2: Patients without OSA undergoing elective coronary bypass surgery.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Consecutive patients undergoing elective coronary artery bypass graft surgery.

Exclusion criteria

Exclusion criteria: •Global respiratory failure •Heart failure (NYHA III-IV) •Acute myocardial infarction •Immune suppression for any reason (for example AIDS,leukaemia, chemotherapy) •Alcoholic disease •Progressive cancer disease •Renal failure requiring dialysis •Pretreated OSA (CPAP-therapy) •Hepatic failure (Child-Pugh C)

Design outcomes

Primary

Measure	Time frame
Composite end point of postoperative cardiac (reanimation, cardiogenic shock, myocardial ischemia, implantation of a permanent pacemaker), respiratory (acute respiratory failure, reintubation, tracheostomy, prolonged mechanical ventilation >24 hours), neurological (stroke), surgical (reoperation), renal (acute renal failure requiring dialysis), infectious (sepsis, deep wound infection, pneumonia) complications, occurring within 7 days or death within 30 days after coronary artery bypass graft surgery in relation to preexisting OSA.	—

Measure

Time frame

Composite end point of postoperative cardiac (reanimation, cardiogenic shock, myocardial ischemia, implantation of a permanent pacemaker), respiratory (acute respiratory failure, reintubation, tracheostomy, prolonged mechanical ventilation >24 hours), neurological (stroke), surgical (reoperation), renal (acute renal failure requiring dialysis), infectious (sepsis, deep wound infection, pneumonia) complications, occurring within 7 days or death within 30 days after coronary artery bypass graft surgery in relation to preexisting OSA.

—

Secondary

Measure	Time frame
•Hospital length of stay (days) •Length of postoperative stay on ICU (hours) •ICU transferral (events) •Postoperative cardiac complications and interventions •Postoperative respiratory complications and interventions •Postoperative neurological complications •Postoperative surgical complications and interventions • Postoperative acute renal failure, requiring dialysis • Postoperative infectious complications •Postoperative SIRS, Sepsis and septic shock •Length of postoperative mechanical ventilation •Reanimation •Mortality at discharge from hospital and within 30 days after surgery •Predispositional factors for infectious complications in OSA such as autonomic, endothelial dysfunction, proinflammatory state and hypercoagulability	—

Measure

Time frame

•Hospital length of stay (days) •Length of postoperative stay on ICU (hours) •ICU transferral (events) •Postoperative cardiac complications and interventions •Postoperative respiratory complications and interventions •Postoperative neurological complications •Postoperative surgical complications and interventions • Postoperative acute renal failure, requiring dialysis • Postoperative infectious complications •Postoperative SIRS, Sepsis and septic shock •Length of postoperative mechanical ventilation •Reanimation •Mortality at discharge from hospital and within 30 days after surgery •Predispositional factors for infectious complications in OSA such as autonomic, endothelial dysfunction, proinflammatory state and hypercoagulability

—

Countries

Germany

Contacts

Public ContactSven Rupprecht

Center for Sepsis Control and Care (CSCC), University Hospital Jena

Sven.Rupprecht@med.uni-jena.de0049/3641/9323480

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026