Functional imaging of the self-consciousness in schizophrenia and its modulation by psychotherapy - a combined fMRI-MRS study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00000682

Enrollment

Registered

2011-05-04

Start date

2010-11-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F20

Interventions

Group 1: Inpatient psychodynamic psychotherapy

The treatment will last 12 weeks and includes 2 sessions per week, 30 minutes each. Drug treatment is not excluded, and should not be changed during treatment. Group 2: healthy volunteers Group 3: sc

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: ICD 10 Diagnosis F 20

Exclusion criteria

Exclusion criteria: Pregnancy; Physical comorbidity

Design outcomes

Primary

Measure	Time frame
The ratio of signal intensities in the interoceptive and exteroceptive attention will be investigated by combined fMRI-MRS study at two different time points. The second measurement is 8-12 weeks after the first one. The concentration of GABA and glutamate (i. a. in the auditory cortex) is examined at two different Measurement points. The second investigation of the biochemical metabolism takes place after 8-12 weeks. Crucial are significant differences between the schizophrenic group and the healthy subjects group as well as the proportion of patients in which these parameters have significantly improved in the meantime.	—

Measure

Time frame

The ratio of signal intensities in the interoceptive and exteroceptive attention will be investigated by combined fMRI-MRS study at two different time points. The second measurement is 8-12 weeks after the first one. The concentration of GABA and glutamate (i. a. in the auditory cortex) is examined at two different Measurement points. The second investigation of the biochemical metabolism takes place after 8-12 weeks. Crucial are significant differences between the schizophrenic group and the healthy subjects group as well as the proportion of patients in which these parameters have significantly improved in the meantime.

—

Secondary

Measure	Time frame
Ego-psychopathology, clinical symptoms, interpersonal problems and personality organization are measured with psychological (self assessment) test procedure: the SCL 90 (symptom checklist), the IPP (Ego-psychopathology), the IPO (personality organisation), the Questionnaire of psychosis typical structures of Dührsen and Happach, the Questionnaire for self-perception, the BPI (borderline inventory), and the IIP (Interpersonal problems) before and after a psychodynamically oriented psychotherapy. Crucial is the proportion of patients with significant clinically improvements (i.e. achieving outpatient status).	—

Measure

Time frame

Ego-psychopathology, clinical symptoms, interpersonal problems and personality organization are measured with psychological (self assessment) test procedure: the SCL 90 (symptom checklist), the IPP (Ego-psychopathology), the IPO (personality organisation), the Questionnaire of psychosis typical structures of Dührsen and Happach, the Questionnaire for self-perception, the BPI (borderline inventory), and the IIP (Interpersonal problems) before and after a psychodynamically oriented psychotherapy. Crucial is the proportion of patients with significant clinically improvements (i.e. achieving outpatient status).

—

Countries

Germany

Contacts

Public ContactClemens Medlin

Asklepios Fachklinikum Tiefenbrunn

c.medlin@asklepios.com0551/5005-251

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026