Investigation of the predictability of pain after implantation of a total hip endoprosthesis using the nociceptive flexion reflex and the pupillary dilatation reflex

Investigation of the predictability of pain after implantation of a total hip endoprosthesis using the nociceptive flexion reflex and the pupillary dilatation reflex - PainPredictionHTEP

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00000665

Enrollment

110

Registered

2013-04-15

Start date

2013-05-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain R52.9

Interventions

Group 1: Patients that receive a hip prosthesis in a regular operation are investigated before the operation concerning anxiety, depression, pain sensitivity, chronic pain, chronic analgesic medicatio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Implantation of a hip prosthesis, age >= 18 years, completed study information and ability to understand the study information, written informed consent to participate in the study, no participation in other clinical studies while participating in this study

Exclusion criteria

Exclusion criteria: ASA-Health Status > 3, BMI > 35, regional anesthesia and peridural or spinal anesthesia

Design outcomes

Primary

Measure	Time frame
Correlations between the measured reflex thresholds of the nociceptive flexion reflex (NFRT) and the pupillary dilatation reflex (PDR) immediately before the end of the anesthesia and the subjective pain (evaluated using a numerical rating scale (NRS)) directly after the regain of consciousness	—

Secondary

Measure	Time frame
1. Correlations between NFRT and PDR immediately before the end of the anesthesia and the cumulative consumption of analgesics until 1 hour, 2 hours and 24 hours after the operation 2. Correlations between NFRT and PDR immediately before the end of the anesthesia and the time from the end of the infusion of opioids until the regain of stable spontaneous breathing of 8/min 3. Predictive value of NFRT and PDR immediately before the end of the anesthesia for the postoperative pain in comparison to a prediction by age, height, weight, gender, preoperative pain (NRS, Present Pain Index), preoperative reflex thresholds, fear (State-Trait Anxiety Inventory), depression (Hospital Anxiety and Depression Scale), pain catastrophizing (Pain Catastrophizing Scale), pain sensitivity (Pain Sensitivity Questionnaire) and duration of surgery 4. Correlations between NFRT and PDR after regain of consciousness and the subjective pain at the same time 5. Correlations between postoperative pain, hip flexibility and -function (Oxford Hip Score via questionnaire and clinical examination) at 1 day, 1 week, 6 months after the operation and the acute postoperative pain directly after the operation	—

Measure

Time frame

1. Correlations between NFRT and PDR immediately before the end of the anesthesia and the cumulative consumption of analgesics until 1 hour, 2 hours and 24 hours after the operation 2. Correlations between NFRT and PDR immediately before the end of the anesthesia and the time from the end of the infusion of opioids until the regain of stable spontaneous breathing of 8/min 3. Predictive value of NFRT and PDR immediately before the end of the anesthesia for the postoperative pain in comparison to a prediction by age, height, weight, gender, preoperative pain (NRS, Present Pain Index), preoperative reflex thresholds, fear (State-Trait Anxiety Inventory), depression (Hospital Anxiety and Depression Scale), pain catastrophizing (Pain Catastrophizing Scale), pain sensitivity (Pain Sensitivity Questionnaire) and duration of surgery 4. Correlations between NFRT and PDR after regain of consciousness and the subjective pain at the same time 5. Correlations between postoperative pain, hip flexibility and -function (Oxford Hip Score via questionnaire and clinical examination) at 1 day, 1 week, 6 months after the operation and the acute postoperative pain directly after the operation

—

Countries

Germany

Contacts

Public ContactFalk von Dincklage

Klinik für Anästhesiologie m.S. operative Intensivmedizin Charité - Universitätsmedizin Berlin

falk.von-dincklage@charite.de+49 30 450 531227

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 27, 2026