A41.9 G62.8 G72.8 G62.80
Conditions
Interventions
Group 1: no intervention, diagnostic procedures: screening: electroneurographic measurements. visit 1 (1 week after begin of the acute sepsis): MRI of pelvis and thigh, neurological examination, optio
Sponsors
CSCC Jena (Center for Sepsis Control and Care)
Hans Berger Klinik für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with severe sepsis and/or septic shock according to the CSCC Criteria since =4 days. Consent of study participation. Age = 18 years, diagnosis of CIP according to electroneurographic criteria.
Exclusion criteria
Exclusion criteria: Patient has a history of neuromuscular disorders (e.g. polyneuropathy, muscle disease, myasthenia gravis, amyotrophic lateral sclerosis, etc.), known alcohol abuse, known diabetes mellitus, high-dose steroid therapy before sepsis (=16 mg/kg body weight for 5 days), ICU stay =8 days, patient is likely to die within less than 24 hours, participation in another clinical study, contraindication for MRI (e.g. pacemaker)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. MR parameters of nerve tissue: changes in T2-weighted sequences, diffusion weighted sequences, gadolinium-enhancement in the ischiadic nerve, the lumbosacral plexus, and the nerve roots. 2. MR parameters in the muscles: changes in T2-weighted sequences, diffusion weighted sequences, gadolinium-enhancement in the quadriceps muscle. Time points of visitation are in the first week after onset of the acute sepsis and 3 to 4 weeks later. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. MR parameters in correlation to electrophysiological measurements (amplitudes, conduction time) (neuropathy). 2. MR parameters in correlation to muscle biopsy results (myopathy). Time points of visitation are in the first week after onset of the acute sepsis and 3 to 4 weeks later. | — |
Countries
Germany
Contacts
Public ContactHubertus Axer
CSCC Jena (Center for Sepsis Control and Care) Hans Berger Klinik für Neurologie
Outcome results
None listed